Details of the Drug

General Information of Drug (ID: DMVG9YN)

• Drug Name: Fencamfamine
• Synonyms: Euvitol; Fenacamfamin; Fencamfamin; Fencamfamina; Fencamfaminum; Fencanfamina; Reactivan; Fencamfamina [DCIT]; Fencamfamin (INN); Fencamfamin [INN:BAN]; Fencamfamine [INN-French]; Fencamfaminum [INN-Latin]; Fencanfamina [INN-Spanish]; Glucoenergan (TN); Reactivan (TN); N-ethyl-2-phenylbicyclo[2.2.1]heptan-3-amine; N-ethyl-3-phenylbicyclo(2.2.1)heptan-2-amine; 2-Ethylamino-3-phenylnorbornane; 2-Phenyl-3-ethylaminobicyclo(2.2.1)heptane; 2-ethylamino-3-phenylnorcamphane; 3-Phenyl-N-ethyl-2-norbornanamine

Indication

Disease Entry	ICD 11	Status	REF
Depressive fatigue	MG22	Withdrawn from market	[1]

• Therapeutic Class: Central Nervous System Stimulants
• Affected Organisms: Humans and other mammals
• ATC Code:
  N06BA06: Fencamfamine
  N06BA: Centrally acting sympathomimetics
  N06B: PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
  N06: PSYCHOANALEPTICS
  N: NERVOUS SYSTEM
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 215.33
  Logarithm of the Partition Coefficient (xlogp); 3.3
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 1
• Chemical Identifiers:
  Formula: C15H21N
  IUPAC Name: N-ethyl-3-phenylbicyclo[2.2.1]heptan-2-amine
  Canonical SMILES: CCNC1C2CCC(C2)C1C3=CC=CC=C3
  InChI: InChI=1S/C15H21N/c1-2-16-15-13-9-8-12(10-13)14(15)11-6-4-3-5-7-11/h3-7,12-16H,2,8-10H2,1H3
  InChIKey: IKFBPFGUINLYQI-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 14584
  ChEBI ID: CHEBI:134895
  CAS Number: 1209-98-9
  UNII: NME1I5IGBK
  DrugBank ID: DB01463
  TTD ID: D0P3DM

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Depressive fatigue
• ICD Disease Classification: MG22

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	2.50E-02	-0.08	-0.49

References

• [1] Drug information of Fencamfamine, 2008. eduDrugs.
• [2] Dopamine uptake inhibiting versus dopamine releasing properties of fencamfamine: an in vitro study. Biochem Pharmacol. 1983 Aug 1;32(15):2329-31.